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Positive Detection of Plasmid Mediated Colistin Resistant (MCR-1) Gene in Salmonella spp. Isolated from Chickens

The emergence of multidrug resistant (MDR) is a major threat worldwide, and it has become worse with the emergence of resistant towards colistin antibiotic. The plasmid mediated colistin resistant gene (mcr-1) present in the bacteria contribute much to the spread of colistin resistant among Enterobacteriaceae such as Escherichia coli and Salmonella spp. Since the first description of mcr-1 gene in E. coli from food animals in year 2015, numerous reports had revealed a worldwide spread of mcr-1 gene among foodborne pathogen. In Malaysia, there is a lack of data on detection of mcr-1 gene among salmonella strains in food producing animals. Hence, this paper focuses on the detection of mcr-1 gene in Salmonella spp. isolated from chickens in VRI using published primers. A total of 183 salmonella isolates were retrieved from diagnostic cases and were used in this study. 2.18% (4/183) of the isolates were found to carry the mcr-1 gene. This finding supports the existence of mcr-1 gene in Salmonella spp. from chickens in the country. Colistin was recognized as the last resort antimicrobial agent in human for the treatment of multidrug resistant Gram negative bacterial infection, in spite of its toxic effects. Antimicrobial resistant problem become  complex when the bacterial strain carries the mcr-1 gene become highly resistant to the last choice of antibiotic and lead to treatment failure. Inter-agencies collaboration to gather the baseline data on colistin usage is crucial to assess the issue and help to draw guideline to reduce the impact of colistin resistance in Malaysia

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About this Article Paper

Roseliza Roslee. Positive Detection of Plasmid Mediated Colistin Resistant (MCR-1) Gene in Salmonella spp. Isolated from Chickens. 30th Veterinary Association of Malaysia (VAM) Congress. 19th-20th October, 2018. Hilton Hotel, Petaling Jaya, Malaysia.(Abstract of Oral Presentation).

 

Roseliza Roslee  

Veterinary Research Institute  

Corresponding author: edlysza@yahoo.com 


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