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ESTABLISHMENT OF REVERSE GENETIC SYSTEM TO GENERATE A BIVALENT AVIAN INFLUENZA AND NEWCASTLE DISEASE VIRUS VACCINE

•             Newcastle disease is endemic in Malaysia and is caused by virulent Newcastle disease viruses (NDV), and they have significance similar to AIV for the poultry industry.

•             Naturally occurring avirulent NDV strains are routinely used as live vaccines, and the development of a reverse genetics system has provided a method  to generate recombinant NDV-based live virus-vectored vaccines (Steel et al, 2007).

•             Several advantages of using avirulent NDV strains as vaccine vectors- can be administered through drinking water or spraying, making inoculation of large numbers of animals in the field feasible and  the cost of production is lower and the yield of production is greater

•             Due to these advantages, an NDV-based live virus vaccine targeted against AIV could have success in the field in the control of infection and spread of AIV in animals

Dr.Khairul Anuar Muhammad

Veterinary Research Institute, Department of Veterinary Services. 59 Jalan Sultan Azlan Shah, 31400 Ipoh, Perak.

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Dr.Khairul Anuar Muhammad. Establishment Of Reverse Genetic System To Generate A Bivalent Avian Influenza And Newcastle Disease Virus Vaccine. End Report MOSTI


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